Primary Antimitochondrial Activity of the Cancer Drug Methylglyoxal Bis(guanylhydrazone) in Yeast Cells
- 1 July 1980
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 119 (1) , 35-40
- https://doi.org/10.1099/00221287-119-1-35
Abstract
Primary action of methylglyoxal bis(guanylhydrazone) (MGBG) on the yeast [Saccharomyces cerevisiae] mitochondrial system was demonstrated by selective inhibition of cell growth in non-fermentable medium, blockage of mitochondrial synthesis of cytochromes aa3 and b and ultrastructural aberration. The drug caused extensive deletions in mitochondrial DNA detected by an increase in the frequency of the mitochondrial mutant petite but had little or no effect on cell viability. Growth inhibition by MGBG was antagonized by spermidine but neither the polyamine nor MGBG had any effect on growth inhibition by ethidium bromide. Strains showed no cross-correlation in their tolerance to MGBG and ethidium bromide.This publication has 2 references indexed in Scilit:
- The possible role of intracellular polyamines in mitochondrial metabolic regulationBiochemical and Biophysical Research Communications, 1978
- Effect of methylglyoxal-bis (guanylhydrazone), an inhibitor of spermidine and spermine synthesis, on cell cycle traversePublished by Elsevier ,1977