Effect of glucose, phlorizin, and parathyroid extract on renal phosphate transport in chickens

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Abstract
Glucose, phlorizin, and parathyroid extract (PTE) were administered to chickens to determine their effects on phosphate excretion and renal tubular transport of phosphate. Exogenous glucose had no effect, phlorizin decreased phosphate excretion, and PTE increased it. Frequently, PTE increased phosphate excretion by more than one filtered load; phlorizin did not prevent this action of PTE. The results indicate that PTE enhances phosphate secretion rather than simply reducing the reabsorption of filtered phosphate. Furthermore, it seems that phlorizin decreases phosphate excretion by increasing phosphate reabsorption rather than by blocking secretion. This action of phlorizin may be secondary to its inhibition of the reabsorption of endogenous glucose.

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