Complement activation in children with acute malaria.
- 1 October 1974
- journal article
- Vol. 18 (2) , 267-72
Abstract
Low C3 levels were found in the sera of most children with acute Plasmodium falciparum malaria. C4 and C1q levels were very low whilst glycine-rich β-glycoprotein (GBG) levels were only slightly depressed, suggesting that complement activation was occurring via the classical pathway. It is suggested that complement activation may play a part in initiating the complex series of changes that leads to the vascular damage seen in this infection.This publication has 12 references indexed in Scilit:
- The Potential Pathogenic Role of Complement in Dengue Hemorrhagic Shock SyndromeNew England Journal of Medicine, 1973
- REACTION MECHANISM OF THE ALTERNATIVE PATHWAY OF COMPLEMENT FIXATIONThe Lancet, 1973
- The direct antiglobulin test and immunoconglutinin titres in patients with malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1973
- Soluble serum antigens of P. falciparum in nigerians. II. Immunochemical studies.1972
- INTRAVASCULAR COAGULATION IN FALCIPARUM MALARIAThe Lancet, 1972
- BLOOD COAGULATION INITIATION BY A COMPLEMENT-MEDIATED PATHWAYThe Journal of Experimental Medicine, 1971
- SOLUBLE ANTIGENS IN THE BLOOD OF AFRICAN PATIENTS WITH SEVERE PLASMODIUM FALCIPARUM MALARIAPublished by Elsevier ,1968
- Complement in acute experimental malaria. I. Total hemolytic activity.1966
- Complement in acute experimental malaria. II. Alterations in the components of complement.1966
- THE COMPLEMENT CONTENT OF HUMAN SERA WITH ESPECIAL REFERENCE TO MALARIA 1Journal of Clinical Investigation, 1948