Morphological Mutants of Neurospora crassa: Possible Evidence of Abnormal Morphology Due to Changes in DNA Composition

Publisher Website
Google Scholar
Abstract
DNA from seven experimentally induced morphological mutants and the wild type strain 74A of Neurospora crassa showed typical bimodal denaturation profiles in a Gilford 2400 spectrophotometer. The ‘slime’ and ‘ropy’ mutants showed comparatively high proportion of A + T rich DNA sequences. The DNA sequences of the slime mutant were distinctly different from those of parental DNA as well as other wild type DNAs. No such difference was noticed in any other mutant and natural isolate of the species N. crassa tested. These studies indicate possible correlation between a change in DNA nucleotide sequences and abnormal morphogenesis.

This publication has 0 references indexed in Scilit: