Efficacy of 9-β- d -Arabinofuranosylhypoxanthine 5′-Monophosphate in Therapy of Equine Abortion Virus-Induced Hepatitis in Hamsters
Open Access
- 1 October 1975
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 8 (4) , 474-478
- https://doi.org/10.1128/aac.8.4.474
Abstract
Equine abortion virus (EAV)-induced hepatitis in hamsters presents an interesting animal model for the evaluation of drugs possessing anti-deoxyribonucleic acid virus activity. These experiments demonstrate that 9-β- d -arabinofuranosylhypoxanthine 5′-monophosphate (ara-HxMP), a new synthetic, water-soluble, antiviral agent, effectively controls this disease in hamsters with a therapeutic index of ∼60. Ara-HxMP prevented hepatitis-associated deaths in hamsters, reduced the titer of EAV developing in hamsters, and inhibited the increase of serum glutamic pyruvic transaminase in EAV-infected hamsters.Keywords
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