EFFECT OF DIETARY SUBSTANCES ON CHOLATE SYNTHESIS IN THE DOG

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Abstract
The ability of various substances to increase cholic acid synthesis was detd. quantitatively in biliary fistula dogs by feeding them alone or as supplements to mixed or synthetic diets. Lard had no effect on cholate synthesis, and sucrose inhibited cholate synthesis from other dietary substances but did not decrease fasting cholate output. Liver concentrate, commercial casein, zein, and a mixed dog food increased cholate synthesis, whereas enzymatic casein hydrolysate, Brewer''s yeast, gelatin, and a synthetic multivitamin mixture were without effect. Cholate outputs when a mixed diet and commercial casein were fed together, and when liver concentrate and casein hydrolysate were given together, were greater than could be accounted for by their individual additive effects. This synergism indicates that at least 2 dietary factors are concerned in cholepoiesis, and that certain foods lack one and other foods lack another necessary factor.
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