Difference in the target cells for tolerance induction in relation to the dose of tolerogen.

  • 1 October 1972
    • journal article
    • Vol. 23  (4) , 537-44
Abstract
Bone marrow cells and thymus cells were observed in cell transfer experiments to collaborate in the production of anti-BSA antibodies. The target cells for tolerance induction either with a `low dose' of antigen (100 μg of deaggregated BSA once a week × 5) or with a `high dose' (a single injection of 5000 μg) were identified by the same technique. In `low dose' tolerance, some indication was obtained that thymus-derived cells in peripheral lymphoid systems were the target cells; bone marrow-derived cells appeared not to be so susceptible, and the cells residing in thymus or bone marrow seemed to remain unimpaired. In contrast, the injection of a `high dose' of tolerogen rendered both types of cells in spleen, thymus cells and bone marrow cells, unresponsive or hyporesponsive in parallel with one another.

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