Desacetylmethylcolchicine in Acute Gouty Arthritis

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Abstract
COLCHICINE has been the drug of choice for the treatment of patients with attacks of acute gouty arthritis because it usually causes prompt and effective symptomatic relief.1 , 2 Despite its dramatic, favorable effect in ameliorating the symptoms of this acute arthritis, it may cause gastrointestinal disturbances such as nausea, vomiting and diarrhea, or a combination of these symptoms, which are so severe in some patients as to prevent its use.Recent investigations with derivatives of colchicine have shown that although these compounds may retain potent antimitotic activity they produce less systemic toxicity in normal and tumor-bearing mice.3 4 5 6 A natural alkaloid, differing . . .