Lack of TRH-Induced TSH Secretion in a Patient with Klinefelter's Syndrome: a Case Report
- 1 January 1975
- journal article
- case report
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 22 (3) , 269-273
- https://doi.org/10.1507/endocrj1954.22.269
Abstract
In a 41 year-old patient with Klinefelter's syndrome, a failure of TRH-induced TSH secretion was noticed. Low 131I-thyroid uptake, together with the elevation following exogenous TSH administration, indicates that the defective locus exists in the hypothalamus or pituitary resulting in an impaired secretion of TSH. Such a defect may underlie thyroid dysfunction often associated with Klinefelter's syndrome.Keywords
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