Some Impacts of Clinical Investigation on Immunology

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Abstract
The interdependence of physiology and medicine is nowhere more obvious than in the field of immunology. Numerous examples can be cited in which careful clinical observation and study of materials obtained from patients have led to the elucidation of important biologic phenomena and have found immediate application to our understanding of pathologic processes. This approach is clearly illustrated by the use of myeloma proteins and Bence-Jones proteins (BJP) to delineate the structural and functional heterogeneity of human immunoglobulins and to elucidate the structure of the antibody molecule. These findings quickly proved of value in studying the pathogenesis of diseases in . . .