Effect of atrial natriuretic factor on blood–brain barrier permeability
- 1 June 1989
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 67 (6) , 637-640
- https://doi.org/10.1139/y89-101
Abstract
Recent studies have demonstrated receptors for atrial natriuretic factor on endothelium of intracerebral vessels. The physiological role of these receptors is not known. The present study was undertaken to determine whether atrial natriuretic factor has an effect on blood–brain barrier permeability to protein and ions using horseradish peroxidase and lanthanum as markers of permeability alterations. This study does not demonstrate a significant effect of atrial natriuretic factor on blood–brain barrier permeability mechanisms in steady states.Key words: blood–brain barrier, atrial natriuretic factor, horseradish peroxidase, lanthanum, ultrastructure.This publication has 3 references indexed in Scilit:
- Cerebral endothelial plasma membrane alterations in acute hypertensionActa Neuropathologica, 1986
- Atrial natriuretic factor (ANF) binding sites in brain and related structuresPeptides, 1984
- Increased vesicular transfer of horseradish peroxidase across cerebral endothelium, evoked by acute hypertensionActa Neuropathologica, 1977