Nucleotide sequence coding for the human type IV collagen α2 chain cDNA reveals extensive homology with the NC‐1 domain of α1 (IV) but not with the collagenous domain or 3untranslated region
- 1 June 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 216 (2) , 281-286
- https://doi.org/10.1016/0014-5793(87)80706-8
Abstract
We have isolated two overlapping cDNA clones that provide the complete nucleotide sequence coding for the NC-1 domain and 3′-untranslated region of the α2 chain of human type IV collagen as well as a sequence encoding 232 residues of the collagenous domain. An extensive homology was observed between the sequences of the NC-1 domain of the α1(IV) and α2(IV) chains, but considerably less between the sequences encoding collagenous and 3′-untranslated regions. There were four interruptions in the collagenous sequence studied whereas the comparable region of the α1(IV) chain had only two. A potential oligosaccharide attachment site was found in a 6-residue long interruption of the collagenous domain but none in the NC-1 domain.Keywords
This publication has 23 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- cDNA and protein sequence of the NC1 domain of the α2‐chain of collagen IV and its comparison with α1(IV)FEBS Letters, 1986
- Proposed alignment of helical interruptions in the two subunits of the basement membrane (type IV) collagenFEBS Letters, 1986
- Structure of mouse type IV collagen. Amino-acid sequence of the C-terminal 511-residue-long triple-helical segment of the alpha2(IV) chain and its comparison with the alpha1(IV) chainEuropean Journal of Biochemistry, 1986
- Normal and abnormal aspects of proteinuriaExperimental pathology, 1986
- Amino acid sequence of the non‐collagenous globular domain (NC1) of the α1 (IV) chain of basement membrane collagen as derived from complementary DNAEuropean Journal of Biochemistry, 1985
- Immunohistochemical localization of short chain cartilage collagen (type X) in avian tissues.The Journal of cell biology, 1985
- Structure of human‐basement‐membrane (type IV) collagenEuropean Journal of Biochemistry, 1984
- Covalent Structure of Mouse Type‐IV CollagenEuropean Journal of Biochemistry, 1982
- A Cysteine‐Rich Collagenous Protein from Bovine PlacentaEuropean Journal of Biochemistry, 1981