Identification of Cholesta‐3,5‐dien‐7‐one by Gas Chromatography‐Mass Spectrometry in the Erythrocyte Membrane of Alcoholic Patients

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Abstract
Lipids and oxidized lipids were analyzed by gas chromatography-mass spectrometry in the erythrocyte membranes of alcoholic and control subjects. Cholesta-3,5-dien-7-one and cholesta-trienes were detected in alcoholic samples examined, but not in significant amounts in controls. Levels of polyunsaturated fatty acids (arachidonic acid, 20:4; docosahexaenoic acid, 22:6; and docosatetraenoic acid, 22:4) in alcoholic samples declined significantly, whereas cholesta-3,5-dien-7-one levels increased. A high level of total bilirubin was observed in most patients. A possible mechanism of the accumulation of choletsa-3,5-dien-7-one in the erythrocyte membrane of alcoholics is discussed.

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