Immunologic Competence of Patients With Psoriasis Receiving Cytotoxic Drug Therapy
- 1 June 1965
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 91 (6) , 599-606
- https://doi.org/10.1001/archderm.1965.01600120031006
Abstract
Patients with psoriasis receiving cytotoxic drug therapy and appropriate control subjects were exposed to (1) sensitizing doses of delayed allergens, dinitrochlorobenzene (DNCB), and paranitrosodimethylaniline (NDMA); (2) evocative patches of pentadecylcatechol (PDC); and (3) immunizing doses of a plague vaccine. Psoriatic patients so treated were very difficult to sensitize to DNCB and NDMA, reacted normally to PDC, and generally failed to give a primary or a secondary immune response to plague antigen.Keywords
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