Abstract
Cardiac repolarization abnormalities can be assessed from measurements of the QT duration taken from paper electrocardiogram recordings. Errors associated with determining the end of the T wave are known, but those associated with the start of the Q wave have so far been neglected. The authors quantify the variation in manual identification of the start of the Q wave, and assesses its contribution to errors in the manual measurement of QT. A randomized study of errors in the timing of Q wave initiation from electrocardiograms plotted on paper was conducted. Four electrocardiogram leads were recorded in eight subjects relaxing in a semi-recumbent position. Manual measurements were made of the time of Q wave initiation in 512 electrocardiograms, presented with different superimposed noise, recording speed and recording gain. The greatest mean difference between four cardiologists amounted to 6.7 ms. A recording gain of 5 mm mV-1, in comparison with 10 mm mV-1, resulted in a difference in Q wave timing of 3.2 ms (P-1 are used, the effect of variation in Q determination on QT measurement is likely to be small.