Monoclonal Antibodies Raised against Bovine Anti-Mülterian Hormone: Bovine, Ovine, and Caprine Hormones Share a Set of Identical Epitopes
- 1 December 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 35 (5) , 1217-1225
- https://doi.org/10.1095/biolreprod35.5.1217
Abstract
Monoclonal antibodies (Mabs) have been raised against purified bovine anti-Müllerian hormone (bAMH) in an effort to obtain nonzoospecific reagents. Although the majority of the resulting hybridomas resembled those obtained previously insofar as they recognized only bovine, ovine and caprine AMH, four others, all immunoglobulin Ms, were directed against an epitope shared with AMH of other species, namely rabbit, pig and cat. Both the zoospecific and the conserved epitopes were located close to the site required for biological activity. It is suggested that the similarity between the immunogenic characteristics of bovine, ovine and caprine AMH is in some way related to the fact that AMH in these species is disseminated in the blood stream and may produce freemartinism.Keywords
This publication has 2 references indexed in Scilit:
- Use of monoclonal antibody techniques to study the ontogeny of bovine anti-Mullerian hormoneReproduction, 1983
- Evidence of the Freemartin Condition in the GoatCytogenetic and Genome Research, 1967