Anantin-A peptide antagonist of the atrial natriuretic factor(ANF). I. Producing organism, fermentation, isolation and biological activity.

1 January 1991

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 44 (2) , 164-171
https://doi.org/10.7164/antibiotics.44.164

Abstract

Anantin, a peptide binding to the receptor of the atrial natriuretic factor (ANF) was isolated from a strain of Streptomyces coerulescens. The molecule consists of 17 natural L-amino acids which form a peptidic ring system. It has a MW of 1, 871.0. The chemical composition is C₉₀H₁₁₁ N₂₁O₂₄. The compound was found to bind competitively to ANF-receptors from bovine adrenal cortex (K_d = 0.61 μM). Furthermore, it dose-dependently inhibited the ANF-induced intracellular cyclic guanosine monophosphate accumulation in bovine aorta smooth muscle cells. At the same concentration no agonistic effects were detectable in these cells. Thus, anantin is considered to be the first microbially produced antagonist of the cardiac hormone, ANF.

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