CD34+cell immunoselection from G-CSF-alone-primed peripheral blood in children with low body mass
- 1 October 1995
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 91 (2) , 431-433
- https://doi.org/10.1111/j.1365-2141.1995.tb05318.x
Abstract
Summary. We report the data of CD34+ cell immunoselection from peripheral blood after G-CSF-alone mobilization (lOμg/kg/d s.c.) in nine children with neuroblastoma (median age 4 5 years (2-8), median body weight 16kg (10-20). Leukaphereses were carried out on a Cobe Spectra separator and two consecutive harvests (4 blood volumes processed) were used for immunoselection on a Ceprate(tm) column. The yield of CD34+ cells in the purified fraction was 50% (23-80), with a median number of 2.8xl06 CD34+ cells/kg (1-9-4). All patients were reinfused with selected CD34+ cells after busulfan 600 mg/m2+ melphalan 180mg/m2 and achieved successful haemopoietic recovery.Keywords
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