AFFERENT NERVES EXCITED BY INTESTINAL DISTENTION

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Abstract
Distention of Thiry fistulae in the first'' portion of the jejunum in otherwise normal, conscious dogs resulted in vomiting and anorexia. Vagotomy did not abolish the vomiting or anorexia during intestinal distention. Bilateral splanchnicotomy and excision of the lumbar chain abolished the vomiting response to distention. Splanchnicotomy, vagotomy and section of the lumbar chains abolished all symptoms due to intestinal distention in 2 dogs but anorexia remained in 3 dogs. The anorexia was eliminated in the latter dogs when the remaining lumbar chains were excised. It is concluded that the vomiting excited by intestinal distention is entirely of nervous origin and that the nervous impulses are conducted over the sympathetic nerves. The anorexia may be due to impulses from the vagi and also from the sympathetic nerves.

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