Quantitative Liver Functions after Administration of Allyl Alcohol to Rats

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Abstract
In rats a single dose of allyl alcohol (100 .mu.l/kg body wt) was given to produce periportal liver damage. Prothrombin index was reduced to a minimum after 12 h and reestablished after 24 h. The galactose elimination capacity was not changed. Hepatic glutathione content was unchanged for the 1st 24 h but was then elevated 2-fold. Microsomal p-nitro-anisole demethylation showed a slight initial increase and a subsequent reduction. The pattern of these changes is similar to that seen after centrilobular liver damage from acetaminophen overdose, with the exception that the latter causes glutathione depletion. This indicates that in chemical liver damage ribosomal function, e.g. protein synthesis and drug hydroxylation, is more vulnerable than cytosolic phosphorylation of carbohydrate.

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