Concomitant K- and N-ras gene point mutations in clonal murine lymphoma.
Open Access
- 1 May 1988
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 8 (5) , 2233-2236
- https://doi.org/10.1128/mcb.8.5.2233
Abstract
We have surveyed a panel of induced murine lymphomas for c-ras gene mutations. The K-ras gene seems to be preferentially activated in our system, and there are at least two examples of concomitant K- and N-ras gene mutations in the same tumor. This indicates that in some cases additional ras mutations may contribute to tumorigenesis and is evidence for a role of ras activation in tumor progression.This publication has 20 references indexed in Scilit:
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