Changes in Lymphoreticular Tissues During Growth of a Murine Adenocarcinoma. I. Histology and Weight of Lymph Nodes, Spleen, and Thymus2

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Abstract
The response of murine lymphoreticular tissues to an isologous implanted adenocarcinoma was studied gravimetrically and histologically until the animals died. Blood volume and blood cell response were also measured. The tumor induced a vigorous histological response in both regional and nonregional lymph nodes that was at first immunoblastic and subsequently plasma cell in character, whereas the response in the thymus, though quite marked, was purely immunoblastic. During the later stages of tumor growth, the immunoblastic series of cells, similar to those usually associated with the cell-mediated immune mechanism, disappeared but the plasma cells, possibly related to the humoral response, remained active. Small, round cells disappeared from lymph nodes and thymus and decreased in the spleen but the total number of lymphocytes in the circulating blood increased. Perhaps the rejection of the tumor was abrogated by the selective suppression of the appropriate immunological mechanism. Nonregional lymph nodes and thymus were more involved than in other immunological situations, and this may be a further unique feature of tumor immunology.

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