Synthesis, Structure−Activity Relationships, and Pharmacokinetic Profiles of Nonpeptidic α-Keto Heterocycles as Novel Inhibitors of Human Chymase
- 9 March 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 44 (8) , 1286-1296
- https://doi.org/10.1021/jm000496v
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- Structure–activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitorsBioorganic & Medicinal Chemistry Letters, 2000
- Inhibition of chymase reduces vascular proliferation in dog grafted veinsFEBS Letters, 2000
- Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory diseaseClinical and Experimental Allergy, 1999
- Novel Autocrine and Paracrine Loops of the Stem Cell Factor/Chymase NetworkInternational Archives of Allergy and Immunology, 1999
- No Evidence for an Association between a Variant of the Mast Cell Chymase Gene and Atopic Dermatitis Based on Case-Control and Haplotype-Relative-Risk AnalysesHuman Heredity, 1998
- PURIFICATION AND CHARACTERIZATION OF INTERLEUKIN 1β FROM HUMAN PLANTAR STRATUM CORNEUM. EVIDENCE OF INTERLEUKIN 1β PROCESSING IN VIVO NOT INVOLVING INTERLEUKIN 1β CONVERTASECytokine, 1998
- Chymase cleavage of stem cell factor yields a bioactive, soluble productProceedings of the National Academy of Sciences, 1997
- Mast cells in human fatty streaks and atheromas: implications for intimal lipid accumulationCurrent Opinion in Lipidology, 1996
- Role of mast cell chymase in the extracellular processing of big-endothelin-1 to endothelin-1 in the perfused rat lungBiochemical Pharmacology, 1992
- Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitorsBiochemistry, 1985