A case of severe neonatal thrombocytopenia with schizencephaly associated with anti‐HPA‐1 b and anti‐HPA‐2a
- 1 July 1994
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 87 (3) , 576-579
- https://doi.org/10.1111/j.1365-2141.1994.tb08315.x
Abstract
We report a family with a neonate who was severely damaged by intracranial haemorrhages. These probably occurred before the 20th week of gestation. The neonate had a moderate thrombocytopenia. In the maternal serum anti-HPA-1b and anti-HPA-2a alloantibodies were detected. Third-generation assays were applied to identify the alloantibodies. No other cause for the bleeding was found. Probably the combination of anti-HPA-1b and anti-HPA-2a alloantibodies, directed against the platelet fibrinogen receptor and the von Willebrand receptor, respectively, induced a thrombocytopenia and a thrombocytopathy.Keywords
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