FLUID VOLUMES AND ELECTROLYTE CONCENTRATIONS IN NORMAL RABBITS

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Abstract
The normal values and their random variations for the extracellular fluid compartments in normal rabbits were detd. Serum Na and K concns. were measured by flame spectrophotometry. In 39 animals, the plasma volume (detd. by the T-1824 dye method) was 42.3 [plus or minus] 7.38 cc./kg.; the total blood volume, 69.8 [plus or minus] 9.12 cc./kg.; the thiocyanate space, 217 [plus or minus] 0.56 cc./kg.; and the radiosodium (Na24) space, 263 [plus or minus] 22.1 cc./kg. The serum Na concn. was 131.9 [plus or minus] 7.2 meq./l.; the serum K concn., 4.58[plus or minus]0.56 meq./l. The mean difference between 2 detns. in 29 rabbits was as follows: plasma volume, 4.14 [plus or minus] 3.25 cc./kg.; total blood volume, 6.34 + 5.25 cc./kg.; thiocyanate space, 15.03 [plus or minus] 10.53 cc./kg.; radiosodium space, 16.55 [plus or minus] 15.61 cc./kg. 71 serial detns. were made on 6 rabbits over an aggregate period of 206 days. The results were as follows: plasma volume, 46 [plus or minus] 5.5 cc./kg.; total blood volume, 72 [plus or minus] 8.9 cc./kg.; thiocyanate space, 194 [plus or minus] 21 cc./kg. The values obtained upon'' tissue analyses for total water content and radiosodium space are given.