Faculty Opinions recommendation of Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.

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Abstract
A rare thing, a successful marriage between pharmacology and psychotherapy, demonstrates that the rational application of neurobiological knowledge can indeed result in improved patient care. From the observation that acute treatment with D-cycloserine enhances the learning process underlying extinction of fear in rodents, and that behavioral exposure therapy for humans is very similar to the animal model, the authors tried giving patients D-cycloserine before they underwent psychotherapy for acrophobia. They report a significant reduction in psychiatric symptoms for patients who had exposure therapy combined with D-cycloserine.

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