A note on the effect of amantadine on body temperature in mice
- 1 September 1973
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 25 (9) , 705-707
- https://doi.org/10.1111/j.2042-7158.1973.tb10051.x
Abstract
Amantadine hydrochloride caused a dose-dependent fall in rectal temperature in mice. This response was antagonized by haloperidol, which itself produced some hypothermia, and by pretreatment with α-methyl-p-tyrosine. The mode of action of amantadine and the possible involvement of dopamine in the control of body temperature is discussed.Keywords
This publication has 6 references indexed in Scilit:
- The effect of anti-Parkinsonian drugs on haloperidol-induced inhibition of the conditioned-avoidance response in ratsNeuropharmacology, 1973
- Effects of amantadine on uptake and release of dopamine by a particulate fraction of rat basal gangliaJournal of Pharmacy and Pharmacology, 1972
- The effect of drugs acting on dopamine receptors on the body temperature of the ratLife Sciences, 1972
- Hypothermic effect of apomorphine in the mouseJournal of Pharmacy and Pharmacology, 1972
- Dopamine and noradrenaline releasing action of amantadine in the central and peripheral nervous system: A possible mode of action in Parkinson's diseaseEuropean Journal of Pharmacology, 1971
- Anticataleptic actions of amantadine hydroehlorideNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1970