Comparison of agglutination, complement fixation and immunofluorescence tests in Campylobacter jejuni infections

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Abstract
Good antibody responses usually follow infection with C. fetus ssp. jejuni. A comparison of agglutination, complement fixation and immunofluorescence tests was done on 55 sera from 40 sporadic patients with diarrheal disease and positive cultures for C. fetus ssp. jejuni. Results showed 82% positive with immunofluorescence 62% by complement fixation but only 38% by agglutination, using 2 reference strains (COP and MEL) as antigens. Overall 90% of the 40 patients were positive by 1 or more serlogical tests. Paired sera from 15 patients showed a 4-fold or greater rise in only 5, confirming previous observations that antibody formation occurs early in the course of infection. Perhaps different test systems may be detecting antibodies of different specificities. The value of serological tests was confirmed but further information on serotypes is required for selection of suitable reference strains.

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