Association of Lipoprotein Lipase Gene Variation with the Physiological Components of the Insulin-Resistance Syndrome in the Population of the San Luis Valley, Colorado

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Abstract
Objective A cohort of people (n = 86) was examined in the first few months after insulin-dependent diabetes mellitus (IDDM) diagnosis to evaluate the effect of hyperglycemia on nerve conduction velocities and latencies. Research Design and Methods Unselected cases with IDDM, who were 6–29 yr of age, were identified at diagnosis from a large, geographically defined area of southern Wisconsin. Peripheral nerve conduction was measured on a sample from this cohort. Results Peroneal nerve conduction velocity was significantly inversely related to glycosylated hemoglobin (P Conclusions These findings suggest that as early as 5–6 mo after diabetes diagnosis, and at a time frequently characterized by partial remission of IDDM, hyperglycemia has a role in the acute slowing of nerve conduction velocity. Other factors such as residual endogenous insulin production do not appear to influence these early changes.

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