Le virus de la rubéole. II. Réplication dans les cellules Vero et effets de l'actinomycine D et du cycloheximide

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Abstract
Budding at the plasmic membrane is the primary mode of production of rubella virus in Vero cells. Intense cytopathic effect is observed even if only 10% of the cells are infected. Actinomycin D has little effect on the multiplication of rubella virus but cycloheximide inhibits its growth. This inhibition is probably due to the reduction of cellular protein synthesis and not to a direct action of the inhibitors on the virus multiplication. Viral proteins in infected cells have not been demonstrated. The presence of a viral substance inhibiting normal cellular synthesis is discussed. [Journal translation]