Effect of a Deglycyrrhizinised Liquorice Compound on the Gastric Mucosal Barrier of the Dog

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Abstract
The protective action against mucosal damage of a deglycyrrhizinised liquorice preparation was examined in Heidenhain pouches of four dogs. The net fluxes of hydrogen, sodium and lithium ion were measured before and after exposure of the mucosa to a 10-mM solution of taurocholate at pH 2. Hydrogen ion back diffusion from and sodium gain by the pouch were significantly increased by the bile acid. However, when pouches were first treated with a 1.2-percent aqueous solution of deglycyrrhizinised liquorice, the net increase in flux of H+ after exposure to bile was significantly less. Lithium did not act as a marker for H+ movement, for exposure to the 10-mM bile acid had no effect on mucosal permeability to Li+. These results suggest that deglycyrrhizinised liquorice protects gastric mucosa against the damaging effect of bile.

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