Relationship between Duodenal pH and Pancreatic Secretion in Dogs and Pigs

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Abstract
Thirty-Vella loops of duodenum and pancreatic fistulae were made in 7 dogs. In 14 pigs pancreatic fistulae, duodenal fistulae and low gastroenterostomies were constructed. In both species the volume of pancreatic juice secreted varied directly as the [H+] of solutions introduced into the duodenum. Alkaline solutions in pigs depressed spontaneous and secretin-stimulated secretion. Pancreatic juice produced more profound and prolonged depression of secretion.