Substance Abuse Vaccines
- 23 October 2008
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1141 (1) , 257-269
- https://doi.org/10.1196/annals.1441.027
Abstract
Conventional substance‐abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches, including vaccination to block the effects of these drugs on the brain, are in advanced stages of development. Although several potential mechanisms for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism involves binding of the drug by antibodies in the bloodstream, thereby blocking entry and/or reducing the rate of entry of the drug into the central nervous system. The benefits of such antibodies on drug pharmacodynamics will be influenced by both the quantitative and the qualitative properties of the antibodies. The sum of these effects will determine the success of the clinical applications of antidrug vaccines in addiction medicine. This review will discuss these issues and present the current status of vaccine development for nicotine, cocaine, methamphetamine, phencyclidine, and morphine.Keywords
This publication has 66 references indexed in Scilit:
- Spatial distribution of HIV prevalence and incidence among injection drugs users in St Petersburg: implications for HIV transmissionAIDS, 2008
- Income generating activities of people who inject drugsDrug and Alcohol Dependence, 2007
- My first time: initiation into injecting drug use in Manipur and Nagaland, north-east IndiaHarm Reduction Journal, 2007
- Opiate addiction in China: current situation and treatmentsAddiction, 2006
- Immunotherapy for the treatment of drug abusePharmacology & Therapeutics, 2005
- Effects of Murine-Derived Anti-Methamphetamine Monoclonal Antibodies on (+)-Methamphetamine Self-Administration in the RatThe Journal of Pharmacology and Experimental Therapeutics, 2004
- USE OF ANTI-(+)-METHAMPHETAMINE MONOCLONAL ANTIBODY TO SIGNIFICANTLY ALTER (+)-METHAMPHETAMINE AND (+)-AMPHETAMINE DISPOSITION IN RATSDrug Metabolism and Disposition, 2003
- Vaccination against nicotine during continued nicotine administration in rats: immunogenicity of the vaccine and effects on nicotine distribution to brainInternational Journal of Immunopharmacology, 2000
- Evidence from opiate binding studies that heroin acts through its metabolitesLife Sciences, 1983
- Influence of active and passive immunity on the disposition of dihydromorphine-H3Life Sciences, 1974