RENAL TUMORS IN RATS GIVEN TRISODIUM NITRILOTRIACETIC ACID IN DRINKING-WATER FOR 2 YEARS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 66  (5) , 869-880
Abstract
Albino male rats (196) were given 1000 ppm trisodium nitrilotriacetic acid (NTA) in drinking water for 2 yr. Control rats (192) were given water without NTA. Animals that had a palpable mass or that appeared clinically ill were killed. All surivors were killed at 704 days. A significantly (P < 0.05) higher proportion of the NTA-treated rats died in the first 550 days of the study (19.7% of the NTA-treated rats vs. 11.2% of the controls). The largest difference between the NTA-treated rats and the controls in tumor incidence was associated with renal adenoma. The NTA-treated group contained 25 rats with renal adenomas and 4 with renal adenocarcinomas. Only 5 control rats had renal adenomas; none had renal adenocarcinomas. No statistically significant differences were observed for any of the other tumor types among the NTA-treated rats and the controls. The overall incidence of renal tubular cell hyperplasia and nephritis was similar in the treated and control groups. A significantly greater number of NTA-treated rats had more severe grades of hyperplasia. Thus NTA when administered continuously in drinking water at a concentration of 1000 ppm is tumorigenic to the rat kidney.

This publication has 0 references indexed in Scilit: