Linking Hippocampal Structure and Function to Memory Performance in an Aging Population

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Abstract
Atrophic changes in the hippocampus and the entorhinal cortex play a major role in the memory impairment observed in the early stages of Alzheimer disease (AD).1,2 The hippocampus is central to the formation of new memories and memory consolidation, the process for converting short-term memory into stored or long-term memory.3 The entorhinal cortex relays multimodal processed information from the sensory cortical areas to the hippocampus and information processed by the hippocampus to permanent storage sites in the neocortex.4