Redox regulation of the ryanodine receptor/calcium release channel
- 1 October 2006
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 34 (5) , 919-921
- https://doi.org/10.1042/bst0340919
Abstract
The RyR (ryanodine receptor)/calcium release channel contains a number of highly reactive thiol groups that endow it with redox sensitivity. In general, oxidizing conditions favour channel opening, while reducing conditions have the opposite effect. Thiol modification affects the channel sensitivity to its principal effectors, Ca2+, Mg2+ and ATP, and alters RyR protein interactions. Here, we give a brief account of the major findings and prevailing views in the field.Keywords
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