HIV-1 genetic diversity in Western Brittany, France
Open Access
- 1 September 2002
- journal article
- Published by Oxford University Press (OUP) in FEMS Immunology & Medical Microbiology
- Vol. 34 (1) , 65-71
- https://doi.org/10.1111/j.1574-695x.2002.tb00604.x
Abstract
We describe human immunodeficiency virus type 1 (HIV-1) diversity in Western Brittany, France, and trace the dissemination of HIV-1 non-B subtype infection. The strategy for HIV-1 subtyping used involved subtype specific enzyme immunoassays, heteroduplex mobility assays and phylogenetic analysis of the sequences of env encoding the V3 loop region. Samples were obtained from 567 patients: 465 (82%) were of subtype B and 66 (11.6%) were not (20 were subtype A, 11 subtype C, four subtype D, seven subtype F, five subtype G and 19 others with circulating recombinant forms: 4CRF01_AE, 11CRF02_AG, 1H, 3CRF11_cpx). These findings are consistent with other studies of French populations. There is an epidemiological correlation between subtype B and homosexual or heterosexual contamination in France and between non-B subtype and heterosexual contamination in Africa.Keywords
This publication has 30 references indexed in Scilit:
- HIV Type 1 Genetic Diversity Is a Major Obstacle for Antiretroviral Drug Resistance Hybridization-Based AssaysAIDS Research and Human Retroviruses, 2001
- Determination of Human Immunodeficiency Virus Type 1 Subtypes by a Rapid Method Useful for the Routine Diagnostic LaboratoryClinical and Diagnostic Laboratory Immunology, 2001
- Evidence of Subtype B-Like Sequences in the V3 Loop Region of Human Immunodeficiency Virus Type 1 in Kilimanjaro, TanzaniaAIDS Research and Human Retroviruses, 2000
- Molecular Characterization of a Recombinant HIV Type 1 Isolate (A/G/E/?): Unidentified Regions May Be Derived from Parental Subtype E SequencesAIDS Research and Human Retroviruses, 2000
- HIV Type 1 Genetic Variability in the Northern Part of CameroonAIDS Research and Human Retroviruses, 1999
- Increasing diversity of HIV-1M serotypes in French blood donors over a 10-year period (1985–1995)AIDS, 1997
- Determination of HIV-1 subtypes in injecting drug users in Bangkok, Thailand, using peptide-binding enzyme immunoassay, and heteroduplex mobility assayAIDS, 1995
- Genetic subtyping of human immunodeficiency virus using a heteroduplex mobility assay.Genome Research, 1995
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995
- A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesJournal of Molecular Evolution, 1980