Treatment of Cancer Patients with Endotoxin Induces Release of Endogenous Cytokines

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Abstract
This study sought to determine whether endogenous tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and granulocyte-colony-stimulating factor (G-CSF) were detectable in sera of lipopolysaccharide (LPS)-treated cancer patients. Twenty patients received an intravenous bolus of purified LPS from Salmonella abortus-equi (4.0 ng/kg). Patients were pretreated with ibuprofen (1,600 mg) to prevent constitutional side effects like fever and chills. Serum TNF-α levels increased from

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