CONTROL OF HEPATOCYTE REPLICATION BY 2 SERUM FACTORS
- 1 January 1984
- journal article
- research article
- Vol. 44 (10) , 4414-4419
Abstract
Serum proteins from hepatectomized or control rats were separated by gel permeation chromatography, and assayed for stimulation of hepatocyte proliferation in primary cultures of hepatocytes. Two peaks of activity were seen in the areas of large (> 120,000) and small (< 3000) MW. These activities are different from insulin, epidermal growth factor or vasopressin, and are empirically termed hepatopoietin A and B, respectively. The 2 activities interact in a synergistic manner to stimulate hepatocyte proliferation at rates comparable to that of the whole serum.This publication has 1 reference indexed in Scilit: