Immunokinetics of a Single Dose of Thymopoietin Pentapeptide
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Journal of Immunopharmacology
- Vol. 2 (4) , 567-572
- https://doi.org/10.3109/08923978009026413
Abstract
14 patients with classical or definite rheumatoid arthritis and a low number of E-rosette forming cells were given single doses of 5 mg and 50 mg of thymopo-ietin intravenously. Thymopoietin pentapeptide produced a dose-related sustained increase in E-rosette forming lymphocytes as shown by the decrease of thymopoietin dependent rosetting ratio. A single dose of 50 mg restored the number of E-rosette forming cells to normal after 12 h and this effect lasted 6 to 7 days. With the administration of 5 mg of thymopoietin pentapeptide, the basal values of E-rosette forming cells markedly increased after 12 h and returned to the pretreatment level on the 2nd day. These immunokinetic data clarify some aspects of the clinical pharmacology of thymopoietin pentapeptide and must be considered for a rational schedule of treatment with the drug.Keywords
This publication has 2 references indexed in Scilit:
- Action of Levamisole on E-Rosette Forming Cells and Serum Adenosine Deaminase in Hodgkin's DiseaseJournal of Immunopharmacology, 1979
- Immunokinetics of A Single Dose of LevamisoleJournal of Immunopharmacology, 1979