MODIFICATION OF THE CATABOLIC ACTION OF ACTH IN RATS FED A DIET HIGH IN POTASSIUM1

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Abstract
Groups of normal female rats were maintained on a constant food intake and daily urine collections were made for nitrogen analysis. Experimental animals received an extra 600 mg. per day of KC1 in their diet. ACTH assaying 15 USP units per mg. was given in doses ranging from 10 μg. to 200 μg. per rat per day. At doses of ACTH below 100 μg. per rat per day no significant increase in urinary nitrogen occurred in those animals on the high KC1 diet whereas it did occur in animals onthe control diet. With doses of ACTH of 100 fig. or above per rat per day it occurred in both groups, but was more marked in the control animals. In a previous paper from this laboratory (1) it was reported that the inclusion daily of an extra 600 mg. of KCl in the diet of normal female rats inhibited the catabolic effect of administered ACTH. In these experiments ACTH administration was started.