Differing estrogenic activities for the enantiomers of o,p′-DDT in immature female rats

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Abstract
Female rats (20-21 days) were given single i.p. injections of (.+-.)-o,p''-DDT, (-)-o,p''-DDT or (+)-o,p''-DDT. At 18 h their uteri were excised and the estrogen-sensitive parameters, uterine wet weight and uterine glycogen content were measured. For o,p''-DDT, the levo enantiomer is the more active estrogen in immature female rats. Optical resolutions of other racemic environmental xenobiotics may be important in the evaluation of their biological effects. [The commercial insecticide DDT is technical grade DDT, a mixture of compounds including about 80%, p,p''-DDT and 15-20% o,p''-DDT.].