Multiple Overlapping Epitopes in the Repetitive Unit of the Shed Acute-Phase Antigen from Trypanosoma cruzi Enhance Its Immunogenic Properties
- 1 December 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (12) , 7946-9
- https://doi.org/10.1128/iai.69.12.7946-7949.2001
Abstract
The repetitive shed acute-phase antigen (SAPA) from Trypanosoma cruzi was thoroughly mapped by SPOT peptides and phage display strategies, showing that a single SAPA repeat is composed of multiple overlapping B-cell epitopes. We propose that this intricate antigenic structure constitutes an alternative device to repetitiveness in order to improve its immunogenicity.Keywords
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