EFFECTS OF CLONIDINE ON BASAL AND COLD-STIMULATED TSH SECRETION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 230  (2) , 220-224
Abstract
Clonidine, injected i.p. 20 min before cold exposure, is able to counteract the blockade induced by .alpha.-methyl-p-tyrosine of cold-stimulated release of TSH [thyrotropin] in rats. Under basal conditions the .alpha.-adrenoceptor stimulating agent, administered into the lateral cerebral ventricle (10 .mu.g), produces, at 30 min, a sharp increase in plasma TSH that returns to control levels at 60 min. When the drug is given i.p. (0.4 mg/kg) it causes a significant decrease in plasma TSH 120 min after the treatment.

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