Phosphorothioate Oligonucleotides as Potential Antiviral Compounds Against Human Immunodeficiency Virus and Herpes Viruses
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (1-3) , 155-166
- https://doi.org/10.1080/07328319108046443
Abstract
Phosphorothioate oligonucleotides (S-oligos) with and without sequence specificity complementary to viral genes were found to have activities against human immunodeficiency virus (HIV) and herpes simplex virus type 2. The potential usage of S-oligo as an antisense molecule and as antiviral compound is discussed.Keywords
This publication has 12 references indexed in Scilit:
- Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotidesAntimicrobial Agents and Chemotherapy, 1990
- Effect of Phosphorothioate Homo-oligodeoxy nucleotides on Herpes Simplex Virus Type 2-induced DNA PolymerasePublished by Elsevier ,1989
- Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.Proceedings of the National Academy of Sciences, 1989
- Characterization of oligonucleotide transport into living cells.Proceedings of the National Academy of Sciences, 1989
- Role of RNase H in hybrid-arrested translation by antisense oligonucleotides.Proceedings of the National Academy of Sciences, 1988
- Physicochemical properties of phospborothioate oligodeoxynucleotidesNucleic Acids Research, 1988
- Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.Proceedings of the National Academy of Sciences, 1987
- Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.Journal of Biological Chemistry, 1987
- NUCLEOSIDE PHOSPHOROTHIOATESAnnual Review of Biochemistry, 1985
- Deoxyrbionucleic acid nucleotidyltransferase and deoxyribonuclease from cultured cells infected with herpes simplex virusBiochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1963