Activation of p53-Dependent Apoptosis by Acute Ablation of Glycogen Synthase Kinase-3β in Colorectal Cancer Cells
Open Access
- 15 June 2005
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 11 (12) , 4580-4588
- https://doi.org/10.1158/1078-0432.ccr-04-2624
Abstract
Purpose: The restoration of checkpoint mechanisms may provide a rational anticancer approach, but the molecular circuitries of how this can be achieved therapeutically are poorly understood. A pivotal signaling network in colorectal cancer cells involves glycogen synthase kinase-3β (GSK3β), a multifunctional kinase whose role in tumor cell survival is not defined.Keywords
This publication has 34 references indexed in Scilit:
- Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growthOncogene, 2004
- Survivin, versatile modulation of cell division and apoptosis in cancerOncogene, 2003
- Beyond Herceptin and GleevecCurrent Opinion in Chemical Biology, 2003
- The specificities of protein kinase inhibitors: an updateBiochemical Journal, 2003
- Inactivation of p21Sensitizes Cells to Apoptosis via an Increase of Both p14ARF and p53 Levels and an Alteration of the Bax/Bcl-2 RatioJournal of Biological Chemistry, 2002
- IAP proteins: blocking the road to death's doorNature Reviews Molecular Cell Biology, 2002
- Lithium Inhibits Cell Cycle Progression and Induces Stabilization of p53 in Bovine Aortic Endothelial CellsJournal of Biological Chemistry, 2001
- Activation of p53 by roscovitine-mediated suppression of MDM2 expressionOncogene, 2001
- Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia ChromosomeNew England Journal of Medicine, 2001
- Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon CarcinomaScience, 1997