Altered Karyotypes of Transplantable “Diploid” Tumors2

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Abstract
Several transplantable rat hepatomas were reported to show “normal” diploid chromosome patterns. Two such tumors, originally induced by treatment of host animals with chemical carcinogens and designated 7800 and 9121, were studied with staining techniques (quinacrine and trypsin-Giemsa) that demonstrated intrachromosomal banding patterns. The 7800 tumor had minor variations in karyotype within the range seen among nontumor cells. The 9121 tumor was characterized by asymmetry of. the #2 chromosomes, 1 of which had a consistently abnormal banding pattern. Some cells also had 43 chromosomes with an extra small telocentric chromosome. Thus using banding techniques for chromosome analysis, we observed a consistent abnormal banding pattern in a proportion of cells with a diploid chromosome number from tumor line 9121. In addition, both diploid tumors showed numerical variation and alteration in the sex chromosomes.

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