The total synthesis of (+)-ryanodol. Part III. Preparation of (+)-anhydroryanodol from a key pentacyclic intermediate
- 1 January 1990
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 68 (1) , 153-185
- https://doi.org/10.1139/v90-023
Abstract
This paper reports several studies that were carried out to learn how to transform the dextrorotatory pentacyclic key intermediate 5 into (+)-anhydroryanodol (6). This transformation requires 24 steps, and takes place via the following intermediates: 5 → 11 → 19 → 34 → 36 → 39 → 144 → 150 → 6. The preparation of the key pentacyclic intermediate 5 is reported in Parts I and II of this series. Keywords: anhydroryanodol, ryanodol, diterpene, organic synthesis, strategy.This publication has 2 references indexed in Scilit:
- The total synthesis of (+)-ryanodol. Part I. General strategy and search for a convenient diene for the construction of a key tricyclic intermediateCanadian Journal of Chemistry, 1990
- The total synthesis of (+)-ryanodol. Part II. Model studies for rings B and C of (+)-anhydroryanodol. Preparation of a key pentacyclic intermediateCanadian Journal of Chemistry, 1990