Isolation and characterization of lipocortin (lipomodulin)
- 1 January 1986
- journal article
- corticosteroid actions-in-infalmmation
- Published by Springer Nature in Inflammation Research
- Vol. 17 (3-4) , 263-266
- https://doi.org/10.1007/bf01982617
Abstract
Summary Lipocortin is a phospholipase inhibitory protein whose synthesis is induced in various cells by glucocorticoids. At least three species with molecular weights of 40,000, 30,000, and 15,000 are presently known. This protein mimics the anti-inflammatory action of glucocorticoidsin vitro as well asin vivo. The synthesis of the protein appears to be associated with the MHC genes.Keywords
This publication has 18 references indexed in Scilit:
- Adrenergic receptors: Possible mechanism of inverse regulation of α- and β-receptorsJournal of Allergy and Clinical Immunology, 1985
- Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.Proceedings of the National Academy of Sciences, 1985
- Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.Proceedings of the National Academy of Sciences, 1984
- Relationship between the anti-phospholipase and anti-inflammatory effects of glucocorticoid-induced proteinsEuropean Journal of Pharmacology, 1984
- Identification of several species of phospholipase inhibitory protein(s) by radioimmunoassay for lipomodulinBiochemical and Biophysical Research Communications, 1982
- H-2 Histocompatibility Region: Influence on the Murine Glucocorticoid Receptor and Its ResponseScience, 1982
- Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.Proceedings of the National Academy of Sciences, 1981
- A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.Proceedings of the National Academy of Sciences, 1980
- The role of glucocorticoid receptor and gene expression in the anti-inflammatory action of dexamethasoneNature, 1979
- Mechanism of action of glucocorticoidsMetabolism, 1974