An Expeditious Synthesis of 4(5) [3-Aminopropyl] Imidazole

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Abstract
Inpmmidine 1is a highly potent and selective agonist for histamine receptors.1 The synthesis of inpmnidine and structure activity considerations have recently been described. Inpmmidine also has potential valus for the tEatrnent of catecholamine-insensitive congestive heart failure.3 It has been noted,3 however, that the synthesis of inpromidine is too canplicated and very expensive. One reason for this is the difficulty associated with the synthesis of the crucial inter mxiiate 4(5) [3-aminopmpyl] imidazole 2hereafter referred to as imi damlylpmpylamine.